ABSTRACT
Objective:To explore influence of rehabilitation pathway treatment on therapeutic effect and prognosis of patients with non -ST elevation myocardial infarction(NSTEMI)undergoing percutaneous coronary intervention (PCI).Methods:A total of 120 NSTEMI patients undergoing PCI treated in our hospital were selected.They were randomly and equally divided into routine treatment group and rehabilitation pathway group.Therapeutic effect,in-cidence of complications,scores of self -rating anxiety scale(SAS),self-rating depression scale(SDS)and quality of life(QOL)before and after treatment were observed,measured and compared between two groups.Results:Af-ter treatment,total effective rate of rehabilitation pathway group was significantly higher than that of routine treat-ment group(91.7% vs.75.0%,P=0.014).Compared with before treatment,after treatment,there were signifi-cant reductions in scores of SAS and SDS,and significant rise in QOL score in both groups(P=0.001 all);com-pared with routine treatment group after treatment,there were significant reductions in scores of SAS[(50.3 ± 4.8) scores vs.(31.9 ± 4.3)scores]and SDS[(49.6 ± 4.1)scores vs.(32.7 ± 3.8)scores],and significant rise in QOL score[(72.9 ± 5.8)scores vs.(83.6 ± 6.3)scores]in rehabilitation pathway group,P=0.001 all.Incidence rate of complications in rehabilitation pathway group was significantly lower than that of routine treatment group(10.0%vs.26.7%,P=0.018).Conclusion:Rehabilitation pathway treatment can alleviate emotions of anxiety and depres-sion,improve quality of life and therapeutic effect,and reduce incidence of complications in patients with non -ST elevation myocardial infarction undergoing percutaneous coronary intervention.
ABSTRACT
Uterine leiomyoma causes considerable morbidity in women. This study systematically reviewed the efficacy and safety of gasless laparoscopic myomectomy (GLM) in the management of uterine leiomyoma by comparing GLM with other minimally invasive procedures. Cochrane Library, Pub- Med, EMBASE, Web of Science, WANFANG database and China National Knowledge Infrastructure (CNKI) were searched for studies published in English or Chinese between January 1995 and May 2015, and related references were traced. Study outcomes from randomized controlled trials and retrospective cohort studies were presented as mean difference (MD) or odds ratio (OR) with a 95% confidence interval (CI). Seventeen studies (including 1862 patients) meeting the inclusion criteria, including 934 treated with GLM and 928 treated with other minimally invasive procedures were reviewed. The results of meta-analysis revealed that GLM resulted in significantly shorter operating time [MD=-10.34, 95% CI (-18.12,-2.56), P<0.00001], shorter hospital stay [MD=-0.47, 95% CI (-0.88,-0.06)], less time to flatus [MD=-2.04, 95% CI (-2.59,-1.48)], less postoperative complications [OR=0.20, 95% CI (0.06, 0.62)] and less blood loss [MD =-30.74, 95% CI (-47.50,-13.98)]. On the other hand, there were no significant differences in duration of post-operative fever [MD=-0.52, 95% CI (-1.46, 0.42)] between the two groups. Additionally, GLM was associated with lower febrile morbidity, lower postoperative abdominal pain, and higher postoperative hemoglobin than other minimally invasive procedures for the treatment of uterine leiomyoma. In conclusion, GLM and other minimally invasive procedures are feasible, safe, and reliable for uterine leiomyoma treatment. However, available studies show that GLM is more effective and safer than other minimally invasive approaches.
Subject(s)
Adult , Female , Humans , Middle Aged , Laparoscopy , Methods , Leiomyoma , General Surgery , Minimally Invasive Surgical Procedures , Methods , Postoperative Complications , Uterine Neoplasms , General SurgeryABSTRACT
Uterine leiomyoma causes considerable morbidity in women. This study systematically reviewed the efficacy and safety of gasless laparoscopic myomectomy (GLM) in the management of uterine leiomyoma by comparing GLM with other minimally invasive procedures. Cochrane Library, Pub- Med, EMBASE, Web of Science, WANFANG database and China National Knowledge Infrastructure (CNKI) were searched for studies published in English or Chinese between January 1995 and May 2015, and related references were traced. Study outcomes from randomized controlled trials and retrospective cohort studies were presented as mean difference (MD) or odds ratio (OR) with a 95% confidence interval (CI). Seventeen studies (including 1862 patients) meeting the inclusion criteria, including 934 treated with GLM and 928 treated with other minimally invasive procedures were reviewed. The results of meta-analysis revealed that GLM resulted in significantly shorter operating time [MD=-10.34, 95% CI (-18.12,-2.56), P<0.00001], shorter hospital stay [MD=-0.47, 95% CI (-0.88,-0.06)], less time to flatus [MD=-2.04, 95% CI (-2.59,-1.48)], less postoperative complications [OR=0.20, 95% CI (0.06, 0.62)] and less blood loss [MD =-30.74, 95% CI (-47.50,-13.98)]. On the other hand, there were no significant differences in duration of post-operative fever [MD=-0.52, 95% CI (-1.46, 0.42)] between the two groups. Additionally, GLM was associated with lower febrile morbidity, lower postoperative abdominal pain, and higher postoperative hemoglobin than other minimally invasive procedures for the treatment of uterine leiomyoma. In conclusion, GLM and other minimally invasive procedures are feasible, safe, and reliable for uterine leiomyoma treatment. However, available studies show that GLM is more effective and safer than other minimally invasive approaches.
ABSTRACT
Objective: To investigate the changes of gene expression in CD34+ hematopoietic stem and progenitor cells (HSPCs) under different growth environments. Methods: Umbilical cord blood mononuclear cells (UCB MNCs) were cultured in static and stirred systems. After 7 days of culture, CD34+ cells were isolated and total RNA was extracted. Gene expression patterns of CD34+ cells from fresh, static and stirred cultures were compared using differential display (DD). Results: 30 gene fragments displayed differential expression levels based on the conditions of DD. One of differentially expressed genes was identified as RAN, which is a member of oncogene RAS family. This gene may be associated with proliferation of hematopoietic cells. Conclusion: Different growth environments induced differential gene expression patterns of CD34+ HSPCs. These differentially expressed genes would give new insights into optimizing in vitro environments for expanding hematopoietic cells.